Neuropathological findings in new variant CJD and experimental transmission of BSE
نویسندگان
چکیده
منابع مشابه
Preclinical Detection of Variant CJD and BSE Prions in Blood
The emergence of variant Creutzfeldt Jakob Disease (vCJD) is considered a likely consequence of human dietary exposure to Bovine Spongiform Encephalopathy (BSE) agent. More recently, secondary vCJD cases were identified in patients transfused with blood products prepared from apparently healthy donors who later went on to develop the disease. As there is no validated assay for detection of vCJD...
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An earlier POST report1 described what was known of the origin of BSE in cattle, and the basis for concern that ‘new variant’ forms of a human transmissible spongiform encaphalopathy (TSE) Creutzfeldt-Jacob Disease (CJD) had a BSE origin. A second report reviewed mathematical models which had helped understand the spread of BSE in cattle and predict what would happen to the future course of the...
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Abbreviations: BSE, bovine spongiform encephalopathy; CWD, chronic wasting disease; GSS, Gerstman–Str€aussler–Scheinker disease; M, methionine; PPS, pentosan polysulphate; PrP, protease-resistant prion protein; PrP, abnormal prion protein; QuIC, quaking-induced conversion; TSE, transmissible spongiform encephalopathy; V, valine; vCJD, variant Creutzfeldt–Jakob disease; VPSPr, variably protease-...
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Up until February 2006, variant CJD (vCJD), the human disease associated with transmission of BSE from cattle, has been confirmed in 160 patients resident in the UK and 28 elsewhere, some of whom have never visited the UK. Cases have been reported in France (16 cases), Ireland (3), USA (2), Canada, Italy, Japan, The Netherlands, Portugal, Saudi Arabia and Spain (1 each). The presumed main perio...
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ژورنال
عنوان ژورنال: FEMS Immunology & Medical Microbiology
سال: 1998
ISSN: 0928-8244,1574-695X
DOI: 10.1111/j.1574-695x.1998.tb01153.x